Abstract
Background and purposes: Assessing liver fibrosis is very necessary for diagnosis, follow- up the response to treatment and prognosis. Data about the evaluation of ARFI and NAFLD fibrosis score in assessment of liver fibrosis in patients with NAFLD in Viet Nam is still limited. This study is aimed at determining the SWV by ARFI and NFS and related factors in patients with NAFLD.
Patients and method: 106 patients of NAFLD were assessed SWV by techniques of ARFI and NAFLD fibrosis score (NFS) at Minh Anh International Hospital, from March 2021 to February 2022.
Results: SWV, performed by ARFI, was 1.05 ± 0.40 (m/s); NFS was -1.93 ± 1.35. A positive correlation between NFS and liver fibrosis stages assessed by ARFI (r=0.43; p<0.001) was found. SWV was positively correlated with age (OR=0.009, p<0.05) and BMI (OR=0.02, p<0.05), negatively correlated with platelet counts (OR=-0.002, p=0.001). A relationship between NFS with age, diabetes mellitus, fasting glycemia, platelet, albumin was found in a multivariate linear regression (p<0.05).
Conclusion: A remarkable percentage of NAFLD patients had liver fibrosis ≥ F2. SWV was positively correlated with age, BMI and negatively correlated with platelet count. NFS was correlated with age, BMI, glycemia, albumin and platelet
Published | 2025-04-24 | |
Fulltext |
|
|
Language |
|
|
Issue | Vol. 15 No. 1 (2025) | |
Section | Original Articles | |
DOI | 10.34071/jmp.2025.1.7 | |
Keywords | NAFLD, AFRI, xơ hoá gan, SWV, NFS NAFLD, AFRI, liver fibrosis, SWV, NFS |

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
Ahmed, M. Non-alcoholic fatty liver disease in 2015, World Journal of Hepatology. 2015,7(11), pp.1450-1459.
Chitturi, S., Farrell, G. C., Hashimoto, E., Saibara, T., Lau, G. K., Sollano, J. D., & Asia–Pacific Working Party on NAFLD. Non‐alcoholic fatty liver disease in the Asia–Pacific region: Definitions and overview of proposed guidelines. Journal of Gastroenterology and Hepatology. 2007, 22(6), pp.778-787.
Trần Thị Khánh Tường. Đánh giá xơ hóa gan nặng bằng phối hợp kỹ thuật ARFI với thang điểm xơ hóa NAFLD trên bệnh nhân viêm gan nhiễm mỡ không do rượu. Tạp chí Y - Dược học quân sự. 2019,(3), pp. 12-20.
Marella, H. K., Reddy, Y. K., Jiang, Y., et al. Accuracy of noninvasive fibrosis scoring systems in african american and white patients with nonalcoholic fatty liver disease. Clinical and Translational Gastroenterology. 2020, 11(4), p. e00165.
Selvaraj, E. A., Mózes, F. E., Jayaswal, A. N. A., Zafarmand, M. H., Vali, Y., Lee, J. A.,... & Doward, L. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. Journal of hepatology. 2021, 75(4), 770-785.
Leong, W. L., Lai, L. L., Nik Mustapha, N. R., et al. Comparing point shear wave elastography (ElastPQ) and transient elastography for diagnosis of fibrosis stage in non‐alcoholic fatty liver disease. Journal of gastroenterology and hepatology. 2020,35(1), pp. 135-141.
Mikolasevic, I., Domislovic, V., Krznaric-Zrnic, I., et al. The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. Medicina. 2022,58(2), p.252.
Vernon G., Baranova A., Younossi Z. M. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011,34 (3), pp. 274-285.
Eddowes, P. J., Sasso, M., Allison, M., Tsochatzis, E., Anstee, Q. M., Sheridan, D., ... & Newsome, P. N. Accuracy of FibroScan controlled attenuation parameter and liver stiffness measurement in assessing steatosis and fibrosis in patients with nonalcoholic fatty liver disease, Gastroenterology. 2019, 156(6), pp.1717-1730.
Nguyễn Thị Việt Hồng. Nghiên cứu kháng insulin trên bệnh nhân gan nhiễm mỡ không do rượu tại Bệnh viện Đa khoa Trung ương Thái Nguyên. Luận văn thạc sĩ y học , Trường Đại học Y Dược Thái Nguyên. 2012.
Phạm Hồng Phương. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và tổn thương động mạch vành ở bệnh nhân bệnh gan nhiễm mỡ không do rượu. Luận án Tiến sĩ Y học, Viện nghiên cứu khoa học y dược lâm sàng 108. 2018.
Trương Thị Ái Phương. Nghiên cứu đánh giá xơ hóa gan trên bệnh nhân viêm gan nhiễm mỡ không do rượu bằng kỹ thuật ARFI phối hợp với chỉ số xơ hóa NAFLD. Luận án chuyên khoa cấp II, Đại học Y Dược Huế. 2015.
Zambrano-Huailla R., Guedes L., Stefano J. T., de Souza A. A. A., et al. Diagnostic performance of three non-invasive fibrosis scores (Hepamet, FIB-4, NAFLD fibrosis score) in NAFLD patients from a mixed Latin American population. Ann Hepatol. 2020,19 (6), pp. 622-626.
Fierbinteanu Braticevici, Sporea I., Panaitescu E., Tribus L. Value of acoustic radiation force impulse imaging elastography for non-invasive evaluation of patients with nonalcoholic fatty liver disease. Ultrasound Med Biol, 2013, 39 (11), pp. 1942-1950.
Yoneda M., Suzuki K, Kato S, Fujita K, et al. Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography. Radiology. 2010,256 (2), pp. 640-647.
Friedrich-Rust, M., Romen, D., Vermehren, J., et al. Acoustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD, European journal of radiology. 2012,81(3), pp. e325-e331.
Rifai K., et al. Clinical feasibility of liver elastography by acoustic radiation force impulse imaging (ARFI). Dig Liver Dis. 2011, 43(6), pp. 491-497.