Tóm tắt
Objectives: To compare AUC24 values between three vancomycin AUC estimation methods, including Bayesian two-concentration, Bayesian one-concentration, and first-order equations.
Materials and methods: A cross-sectional, retrospective study of 67 medical records of adult patients who received vancomycin therapy drug monitoring based on AUC at the Intensive Care Unit - Poison Control Department, Nguyen Tri Phuong Hospital, from July 2023 to April 2024.
Results: There was high agreement between Bayesian two-concentration and one-concentration methods (r = 0.974, clinical agreement 91%), and Bayesian twoconcentration method and first-order equations (r = 0.968, clinical agreement 83.6%) with a variability of 95% LOA -150.5 to 98.9 (MD = -25.8 mg.h/L) and 95% LOA -99.3 to 175.8 (MD = 38.3 mg.h/L), respectively. The Bayesian one-concentration and first-order equations had lower agreement than the other comparisons (r = 0.927, clinical agreement 80.6%), showing significant variability with 95% LOA -144.4 to 272.5 (MD = 64 mg.h/L).
Conclusion: The Bayesian two-concentration and one-concentration methods demonstrated the highest agreement. The methods which had significant differences need to be considered for their interchangeability in clinical practice.
| Đã xuất bản | 03-01-2026 | |
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| Số tạp chí | Tập 15 Số 6 (2025) | |
| Phân mục | Nghiên cứu | |
| DOI | 10.34071/jmp.2025.6.878 | |
| Từ khóa | AUC, Bayesian, ICU, TDM, vancomycin AUC; Bayesian; ICU; TDM; vancomycin |
công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .
Bản quyền (c) 2025 Tạp chí Y Dược Huế
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