Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Dyslipidemia and insulin resistance are major risk factors for coronary artery disease (CAD).
Objective: To evaluate the association between triglyceride-glucose (TyG) index and novel atherogenicity
indices with the incidence and severity of coronary artery disease.
Materials and methods: A cross-sectional descriptive study was conducted on 246 participants, including 147 with CAD with coronary artery stenosis of more than 50% measured by coronary angiography and 99 control subjects with no symptoms, abnormal electrocardiogram, echocardiogram and cardiac troponin T (control group). Participants were surveyed by questionnaire, clinical examination and biochemical tests.
Results: AIP index, Castelli risk index, non-HDL-C, RLPC, LCI, TyGVB, CHOLINDEX, METS-IR and TyG index were significantly higher in the group with CAD compared with the control group (p < 0.05). In multivariate analysis, TyG, AIP, non-HDL-C, CRI-I, CRI-II indices were higher in CAD patients. ROC analysis showed that the AIP index cut off of 0.1 had a sensitivity of 67.3% and a specificity of 62.6% in predicting CAD risk, while the TyG index cut off of 8.2 had a sensitivity of 39.5% and a specificity of 83.8%. TyG index, METS-IR, RLPC, AIP, and LCI were significantly higher in multi-vessels coronary artery disease group.
Conclusion: Non-traditional lipid indices such as the AIP and TyG indices showed significant differences in predicting CAD risk and multi-vessels coronary artery disease. The TyG and AIP indices may serve as promising biomarkers for predicting CAD, but larger studies are needed in the future.
| Published | 2026-03-30 | |
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| Issue | Vol. 16 No. 1 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.6.1023 | |
| Keywords | Bệnh động mạch vành, chỉ số sinh vữa xơ động mạch huyết tương (AIP), chỉ số triglyceride-glucose (TyG) Coronary artery disease, plasma atherosclerosis index (AIP), triglyceride-glucose index (TyG) |
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Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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