Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Anemia in rheumatoid arthritis (RA) is a condition associated with chronic inflammation. Early detection and treatment of anemia may contribute to improving patient outcomes. In RA, inflammation is characterized by elevated levels of serum inflammatory markers, notably C-reactive protein (CRP), and disease activity is commonly assessed using the Disease Activity Score 28 (DAS 28).
Objectives: 1. To determine serum CRP levels, DAS 28 CRP, DAS 28 ESR scores, and anemia status in
patients with RA; 2. To investigate the relationship between serum CRP levels, anemia status, and clinical and paraclinical indices in RA patients.
Methods: A cross-sectional descriptive study was conducted on 39 patients diagnosed with RA at Hue University of Medicine and Pharmacy Hospital.
Results: The median serum CRP level was elevated at 45.72 [12.15 - 91.14] mg/L. Two-thirds of patients had high disease activity (DAS 28 > 5.1). Anemia was observed in 51.3% of patients, with microcytic anemia accounting for 7.7% and normocytic anemia for 43.6%. Hypochromic anemia, based on mean corpuscular hemoglobin (MCH), was present in 28.2% of cases. CRP levels showed a strong positive correlation with first
hour erythrocyte sedimentation rate (ESR) (p = 0.001, r = 0.515) and swollen joint count (p < 0.001, r = 0.533), and a moderate positive correlation with tender joint count (p = 0.003, r = 0.463). A significant association was found between anemia and the number of painful joints in patients (p = 0.02).
Conclusion: Most RA patients exhibited elevated CRP levels, high disease activity, and more than 50% had anemia. There was a strong correlation between the DAS 28 CRP and DAS 28 ESR scores. The study found a relationship between anemia, CRP levels, and tender joint count. CRP was strongly correlated with first-hour ESR.
| Published | 2026-03-30 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | Vol. 16 No. 1 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.1.1045 | |
| Keywords | viêm khớp dạng thấp (VKDT), thiếu máu, CRP, DAS 28 CRP, DAS 28 ESR rheumatoid arthritis, anemia, CRP, DAS 28 CRP, DAS 28 ESR |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
Chen YF, Xu SQ, Xu YC, Li WJ, Chen KM, Cai J, et al. Inflammatory anemia may be an indicator for predicting disease activity and structural damage in Chinese patients with rheumatoid arthritis. Clin Rheumatol. 2020;39(6):1737–45.
Hoàng Trung Dũng, Viên Văn Đoan, Đoàn Văn Đệ. Nghiên cứu nồng độ CRP huyết tương ở bệnh nhân viêm khớp dạng thấp. tạp chí Y Dược lâm sàng 108. 2018;13(3).
Triệu Văn Mạnh, Vũ Thị Kim Hải, Hoàng Văn Tổng, Đoàn Văn Đệ, Nguyễn Lĩnh Toàn. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng của bệnh nhân viêm khớp dạng thấp tại Bệnh viện Trung ương Thái Nguyên. Tạp chí Y học Việt Nam. 2023;524(1B).
Greenmyer JR, Stacy JM, Sahmoun AE, Beal JR, Diri E. DAS28‐CRP cutoffs for high disease activity and remission are lower than DAS28‐ESR in rheumatoid arthritis. ACR Open Rheumatol. 2020;2(9):507–11.
El-Tawab SS, Moharram LM, Younis GA, EL Dabah NA, Adel-Naby HM. Study of serum calprotectin level in rheumatoid arthritis: unexpected low level and possible explanations. Egypt Rheumatol Rehabil. 2024;51(1).
Nguyễn Thị Hiền. Nghiên cứu nồng độ vitamin D3 (25-OH), Interleukin-6 huyết thanh và mối liên quan đến mức độ hoạt động bệnh của bệnh viêm khớp dạng thấp [Luận văn Tiến sĩ Y học]. Hà Nội: Trường Đại học Y Hà Nội; 2021.
Mai Quang Huy. Đặc điểm của hội chứng thiếu máu ở bệnh nhân viêm khớp dạng thấp. Tạp chí Y học lâm sàng. 2022;80(9):59–65.
Smyrnova G. The relationship between hemoglobin level and disease activity in patients with rheumatoid arthritis. Rev Bras Reumatol. 2014;54(6):437–40.
Islam MR, Islam MS, Sultana MM. Anemia of Chronic Disease in Rheumatoid Arthritis and its Relationship with Disease Activities. TAJ: Journal of Teachers Association. 2020;33(2): 85–93.
Gonzalez-Lopez L, Rocha-Muñoz AD, Ponce Guarneros M, Flores-Chavez A, Salazar-Paramo M, Nava A, et al. Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis. Journal of Immunology Research. 2014;2014:1–10.
Siemons L, ten Klooster PM, Vonkeman HE, van Riel PL, Glas CA, van de Laar MA. How age and sex affect the erythrocyte sedimentation rate and C-reactive protein in early rheumatoid arthritis. BMC Musculoskeletal Disorders. 2014;15(368).
Kashyap B, Bandyopadhyay D, Ghosh S, Pujani M, Raina P, Agarwal N Correlation of hs-CRP levels with anti-CCP and rheumatoid factor among clinically suspected rheumatoid arthritis cases: A predictor for early inflammation. Ann Pathol Lab Med. 2019;6(9):482–6.