Abstract

Background: Holmium laser enucleation of the prostate (HoLEP) is an effective surgical treatment for benign prostatic hyperplasia (BPH), particularly in patients with large prostate volumes. However, variability in surgical techniques and the prolonged learning curve remain major challenges in clinical practice. Anatomical en bloc HoLEP was developed to maintain a continuous plane between the adenoma and the surgical capsule, thereby facilitating stable enucleation, improved hemostasis, and preservation of urinary function. Objectives: This study aimed to evaluate the early clinical outcomes of anatomical en bloc HoLEP in the management of BPH. Methods: A prospective case-series study was conducted on 101 patients with BPH who underwent anatomical en bloc HoLEP at Binh Duong General Hospital between January and December 2025. Clinical characteristics, perioperative parameters, and postoperative complications were recorded. Functional outcomes including International Prostate Symptom Score (IPSS), quality of life (QoL), peak urinary flow rate