Abstract

Background: Vietnam is confronting a dual burden of disease alongside alarming rates of antimicrobial resistance (AMR), which accounts for an estimated 70,000 annual deaths. The digital health revolution has generated a massive Big Data ecosystem, comprising over 34 million electronic health records across 1,210 hospitals. Methods: This study performed a systematic review and secondary data analysis using the WHO GLASS 2025 report, Ministry of Health statistics, and health insurance verification data from the 2024-2025 period. Results: Non-communicable diseases (NCDs) represent 84% of total mortality, while a resurgence in infectious diseases has been observed. Southeast Asia exhibits the highest global average resistance rate at 31.1%. In Vietnam, resistance to 3rd-generation cephalosporins in E. coli and K. pneumoniae ranges from 55% to over 70%. Carbapenem resistance is increasing at an annual rate of 12 - 15% regionally. Conclusion: Big Data analytics within the national healthcare system serves as a critical instrument for developing effective Antimicrobial Stewardship (AMS) strategies, enabling real-time surveillance and precision clinical decision support.