Abstract

Background: Non-surgical periodontal therapy, including scaling and root planing, is the fundamental approach in the management of periodontal disease. However, treatment outcomes largely depend on the host response. Therefore, adjunctive therapies aimed at improving clinical outcomes have gained increasing attention. Objectives: To evaluate the effectiveness of combined melatonin and vitamin C as adjuncts to non- surgical periodontal therapy. Materials and Methods: A controlled clinical intervention study was conducted on 60 patients with periodontitis, who were divided into two groups: the control group (30 patients) received non-surgical periodontal therapy alone, while the test group (30 patients) received non-surgical periodontal therapy combined with systemic administration of melatonin and vitamin C. Clinical periodontal parameters, including Plaque Index (PlI), Gingival Index (GI), Bleeding on Probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were recorded at baseline, 1 month, and 3 months after treatment. Results: The test group demonstrated statistically significant improvements in Gingival Index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) at 1 month and 3 months compared to baseline, with greater improvements observed compared to the control group (p < 0.05). Conclusion: The adjunctive use of systemic melatonin and vitamin C in non-surgical periodontal therapy 138 TẠP CHÍ Y DƯỢC HUẾ - HUE JOURNAL OF MEDICINE AND PHARMACY ISSN 3030-4318; eISSN: 3030-4326 improves clinical periodontal parameters. Given its minimally invasive nature and potential therapeutic benefits, this approach may be considered for clinical application.