Abstract

Objectives: Objectives: This study aimed to determine the relationship between oxidative stress measured by oxidation-reduction potential (ORP) and semen analysis results in infertile cases, along with factors associated with ORP levels. Methods: This cross-sectional study included 150 men from infertile couples as determined by WHO guidelines. General characteristics, including age, disease history, smoking and drinking habits, semen analysis, sperm chromatin dispersion assay (SCD), and ORP, were evaluated for all subjects. Results: The average age of participants was 34.32 ± 5.43 years old. The mean value of ORP was 0.98 ± 0.90 mV/106 sperm/mL. Patients with a history of smoking and mumps were associated with increased ORP in semen (p = 0.025 and p = 0.035, respectively). Additionally, high BMI patients also had higher ORP results. Conclusion: Infertile men with a history of smoking and a history of mumps increased oxidative stress in semen. Elevated BMI was also a risk factor for oxidative stress in semen. Oxidative stress could be a factor that affects negatively sperm quality.