Abstract
Background: Onychomycosis is a relatively common dermatological disease. C. albicans is the most common yeast pathogenic in this disease. In addition, non - albicans Candida species and other yeast were also causative agents. Non - albicans Candida species were less susceptible to antifungal drugs than C. albicans.
Objectives: 1. To identify yeast species from onychomycosis by cultured on Candida chromogenic agar and carbohydrate assimilation testing by API 20C test. 2. To evaluate antifungal susceptibility testing of Candida isolates by disk difusion method.
Materials and methods: A cross-sectional survey to descri be 39 patients with onychomycosis examined at the Dematology Clinic - Hue University of Medicine and Pharmacy Hospital and Hue City Dermatology Hospital from 10/2023 to 05/2024.
Results: C. parapsilosis was the dominant species isolated (46%), followed by C. albicans 12%, C. tropicalis 16%, C. guilliermondii 8%, and C. famata 4%. Additionally, Trichosporon asahi and Trichosporon muicoides were isolated. All Candida isolates were susceptible to amphotericin B, nystatin, itraconazole, and clotrimazole. The resistance rate of Candida to fluconazole, voriconazole, ketoconazole, and miconazole were 32.6%, 25.6%, 9.3%, and 27.9%, respectively. C. albicans was susceptible to all drugs checked in this study, except for fluconazole. Azole resistance observed in non - albicans Candida species, in which C. tropicalis had the highest resistance rate. Trichosporon spp. were susceptible to all drug tested, except for ketoconazole.
Conclusion: C. parapsilosis was the most common pathogenic species isolated from onychomycosis patients. Non - albicans Candida species were resistance to azole than C. albicans. C. tropicalis had the highest resistance rate to
azole drugs.
| Published | 2025-06-25 | |
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| Issue | Vol. 15 No. 3 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.3.7 | |
| Keywords | Candida, nấm men, nấm móng, thử nghiệm độ nhạy cảm, đề kháng Candida, onychomycosis, yeast, antifungal susceptibility testing, resistance |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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