Abstract
Background: Gastric cancer is one of the most common malignant diseases with a still limited prognosis. In addition to clinical, endoscopic, and histopathological factors, abnormal expression of p53 protein has been reported to be associated with tumorigenesis and disease progression in gastric cancer.
Objectives: (1) To determine the positive expression rate of p53 protein in patients diagnosed with gastric cancer; (2) To evaluate the relationship between p53 protein expression and clinical, endoscopic, and pathological characteristics.
Methods: Cross-sectional, retrospective descriptive study conducted on 53 patients diagnosed with primary gastric carcinoma at Hue University of Medicine and Pharmacy Hospital between May 2023 and April 2025.
Results: The positive rate of p53 expression in patients with primary gastric carcinoma was 37.7% (20/53). Among p53-positive cases, patients aged ≥ 60 years accounted for 85.0%, compared with 15.0% for those aged < 60 years; the difference was statistically significant (p < 0.05). No statistically significant difference in the rate of p53 positivity was observed between male and female patients (p > 0.05).
Conclusion: The positive expression rate of p53 protein in patients with primary gastric carcinoma was 37.7%. P53 expression was significantly associated with age but not with gender, tumor location, size, morphology, histological classification, degree of differentiation, or TNM stage.
| Published | 2026-06-28 | |
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| Issue | Vol. 16 No. 3 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.3.628 | |
| Keywords | p53, ung thư biểu mô dạ dày, giải phẫu bệnh, hóa mô miễn dịch. |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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