Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Gastric cancer is a common malignant disease with a generally poor prognosis. In addition to relying on clinical factors, endoscopic and pathological characteristics, the abnormal expression of the p53 protein has been associated with both the mechanisms of carcinogenesis and patient prognosis. Objectives: (1) Determine the positive expression rate of p53 protein in patients diagnosed with gastric cancer. (2) Evaluate the relationship between p53 protein expression and clinical, endoscopic, and pathological characteristics. Method: Cross-sectional, retrospective descriptive study conducted on 53 patients diagnosed with primary gastric carcinoma at Hue University of Medicine and Pharmacy Hospital between May, 2023 and April, 2025. Results: The p53 protein was positively expressed in 37.7% (20/53). Expression was significantly higher in patients aged ≥ 60 years (85.0%) compared to those < 60 years (15.0%) (p < 0.05), with no significant difference observed between genders. P53 expression was predominantly found in tumors located in the antral-pyloric region (75.0%), with a size ≥ 3 cm (70.0%), ulcerative lesions (55.0%), tubular adenocarcinoma type (70.0%), well or moderately differentiated (40.0%), and TNM stage III–IV (60.0%); however, these associations were not statistically significant (p > 0.05) Conclusion: The positive expression rate of p53 protein in patients with primary gastric carcinoma was 37.7%. P53 expression was significantly associated with age but not with gender, tumor location, size, morphology, histological classification, degree of differentiation, or TNM stage.
| Published | 2026-06-28 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | Vol. 16 No. 3 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.3.628 | |
| Keywords | p53, ung thư biểu mô dạ dày, giải phẫu bệnh, hóa mô miễn dịch. |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
Đặng Công Thuận. Ung thư dạ dày. Trong: Giáo trình Giải phẫu bệnh. Huế: Nhà xuất bản Đại học Huế; 2014. tr. 115.
Bộ Y tế. Hướng dẫn chẩn đoán và điều trị ung thư dạ dày. Hà Nội: Nhà xuất bản Y học; 2022.
Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88(3):323-31.
Müller PAJ, Vousden KH. p53 mutations in cancer. Nat Cell Biol. 2013;15(1):2-8.
Hwang HJ, Nam SK, Park H, et al. Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer. J Pathol Transl Med. 2020;54(5):378-86.
An Q, Miao L, Wu J, Ma J. Mutant pattern of p53 as a feasible predictor of distant metastasis following curative gastrectomy for advanced-stage gastric cancer. J Cancer. 2025;16(3):860-75.
Nguyễn Quang Quyền. Dạ dày. Trong: Bài giảng Giải phẫu học. Tập 2. TP. Hồ Chí Minh: Đại học Y Dược TP.HCM, Nhà xuất bản Y học; 1993. tr. 98.
Im WJ, Lee JH, Kim YW, et al. Tumor size as a prognostic factor in gastric cancer patients. J Gastric Cancer. 2012;12(3):164-71.
Mo H, Guan W, Mo X, et al. Prognosis of multiple gastric cancers compared with solitary gastric cancer after curative resection: a propensity score matching study. BMC Gastroenterol. 2020;20(1):138.
Phạm Minh Anh. Nghiên cứu ứng dụng phân loại mô bệnh học và sự bộc lộ của một số dấu ấn phân tử tiên lượng trong ung thư biểu mô dạ dày [Luận án Tiến sĩ Y học]. Hà Nội: Trường Đại học Y Hà Nội; 2023.
Đặng Công Thuận, Nguyễn Văn Mão. Kỹ thuật hóa mô miễn dịch. Trong: Giáo trình Giải phẫu bệnh. Huế: Nhà xuất bản Đại học Huế; 2022. tr. 147.
Yasui W, Oue N, Kuniyasu H, Ito R, Tahara E, Yokozaki H. Expression of p53 protein in gastric carcinomas: clinicopathological and prognostic significance. J Pathol. 1992;166(3):243-50.
Wu MS, Shun CT, Wang HP, Sheu JC, Lee WJ, Lin JT. Overexpression of p53 protein and its association with mutation of the p53 gene in gastric carcinoma. Cancer. 2000;89(9):1745-52.
Li J, Shen L, Lu H, Li Z. Expression of p53 and its clinical significance in gastric carcinoma. World J Gastroenterol. 2010;16(23):2909-13.
Zhang Y, Li J, Song Y, Chen X, Han Y, Wang Y. Prognostic significance of p53 expression in gastric cancer: a meta-analysis. J Surg Oncol. 2016;113(3):276-83.
Kim MA, Jung EJ, Lee HS, Yang HK, Kim WH. Clinicopathologic characteristics and prognostic factors in gastric carcinoma with p53 overexpression. Korean J Pathol. 2014;48(3):211-8.
Lazar D, Taban S, Sporea I, Dema A, Cornianu M, Lazar E, et al. Expression of p53, Bcl-2, and Ki-67 in gastric cancer: an immunohistochemical study. Rom J Morphol Embryol. 2010;51(3):569-74.
Shin N, Kim JY, Kang GH, Kim KM. Clinicopathologic characteristics of p53 overexpression in gastric carcinoma and its relationship with prognosis. Gastric Cancer. 2015;18(3):583-93.
Oliveira C, Seruca R, Carneiro F. Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol. 2013;21(1):1-19.