Abstract
Background: Colorectal cancer is the third most common cancer worldwide. Microsatellite instability (MSI) results from the functional deficiency of one of the mismatch repair (MMR) proteins, which can be identified using immunohistochemistry. Determining MMR status is crucial for clinicians in diagnosing, prognosticating, and making chemotherapy decisions for CRC patients.
Objectives: (1) To assess the expression status of MMR proteins using immunohistochemistry. (2) To evaluate the association between MMR expression and certain clinicopathological features in colorectal adenocarcinoma.
Materials and methods: A cross-sectional descriptive study was carried out on 81 colorectal cancer patients who were examined and treated at HueUniversity of Medicine and Pharmacy Hospital. The study was conducted from 04/2024 to 03/2025.
Results: Deficient mismatch repair (dMMR) rate was 16%, proficient mismatch repair (pMMR) rate accounted for 84%. The tumors with dMMR status were significantly associated with right-sided location, tumor size larger than 5 cm, and moderate to poor differentiation (p < 0.05). There was no association between dMMR status and age, gender, histological subtype, T stage, lymph node metastasis, or disease stage.
Conclusion: Testing for MMR status should be done for all patients with colorectal cancer, particularly those with right-sided tumors greater than 5 cm in size and high-grade histology.
| Published | 2025-08-30 | |
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| Issue | Vol. 15 No. 4 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.4.8 | |
| Keywords | colorectal cancer, microsatellite instability, mmunohistochemistry, mismatch repair protein |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
WHO. More than 1 million new curable sexually transmitted infections every day [Internet]. 2019 [cited 2024 Aug 12]. Available from: https://www.who.int/news/item/06-06-2019-more-than-1-million-new-curable-sexually-transmitted-infections-every-day
World Health Organization. Global health sector strategy on sexually transmitted infections 2016-2021:toward ending STIs. 2016 [cited 2025 Jan 2]. Available from: https://iris.who.int/handle/10665/246296
Pacific WHORO for the W. Consensus Report on STI, HIV and AIDS Epidemiology : Viet Nam, 2000. 2000[cited 2025 Jan 8]; Available from: https://iris.who.int/handle/10665/207077
Lan PT, Srålsby Lundborg C, Phuc HD, Sihavong A, Unemo M, Chuc NTK, Khang TH, Mogren I. Reproductive tract infections including sexually transmitted infections: a population-based study of women of reproductive age in a rural district of Vietnam. Sex Transm Infect. 2008 Apr;84(2):126–32.
Hoa Ngan Nguyen, Pranee Liamputtong, Gregory Murphy. Knowledge of contraceptives and sexually transmitted diseases and contraceptive practices amongst young people in Ho Chi Minh City, Vietnam. Health Care Women Int. 2006;May;27(5):399–417.
Ha Ngoc Do, Diep Ngoc Nguyen, Hoa Quynh Thi Nguyen, Anh Tuan Nguyen, Hiep Duy Nguyen, Thanh Phuong Bui, Thao Bich Thi Vu, Khiet Thanh Le, Dung Tuan Nguyen, Cuong Tat Nguyen, Linh Gia Vu, Giang Thu Vu, Bach Xuan Chan, Carl A Latkin, Roger CM Ho, Cyrus SH Ho. Patterns of Risky Sexual Behaviors and Associated Factors among Youths and Adolescents in Vietnam. Int J Environ Res Public Health. 2020; Mar 14;17(6):1903.
Van Pham, Hoang Nguyen, Le Huu Tho, Truong Tan Minh, Porntip Lerdboon, Rosemary Riel, Mackenzie S Green, Linda M Kaljee. Evaluation of three adolescent sexual health programs in Ha Noi and Khanh Hoa province, Vietnam. AIDS Res Treat. 2012;2012:986978.
HHS. Reproductive Health and Teen Pregnancy | HHS Office of Population Affairs [Internet]. 2024 [cited 2024 Aug 12]. Available from: https://opa.hhs.gov/adolescent-health/reproductive-health-and-teen-pregnancy
MEDLATEC. Bệnh lây truyền qua đường tình dục - đừng ngại đi khám mà bệnh nặng hơn [Internet]. Bệnh viện đa khoa MEDLATEC. 2020 [cited 2024 Aug 12]. Available from: https://medlatec.vn/tin-tuc/benh-lay-truyen-qua- duong-tinh-duc--dung-ngai-di-kham-ma-benh-nang-hon-s74-n20856/
Phạm Tường Vân, Trương Thuỳ Trang. Khảo sát nhu cầu giáo dục về giới, tình dục và HIV cho sinh viên hệ đại học Y học dự phòng và Y tế công cộng năm học 2013-2014. Tạp chí Y học Dự phòng. 2016;Tập XXVI, số 6(179).
Nguyễn Thị Phương Thanh, Đào Anh Sơn, Nguyễn Đức Hữu Anh, Vũ Minh Tuấn, Nguyễn Thị Thuý Hành. Kiến thức, thái độ về các bệnh lây truyền qua đường tình dục của sinh viên đại học tại Hà Nội năm 2019. Tạp chí Nghiên cứu Y học (Đại học Y Hà Nội). 2020;126(2): 129-137.
Huỳnh Thị Như Thúy, Nguyễn Hoàng Thảo My. Khảo sát sự hiểu biết về việc phòng chống HIV/AIDS của sinh viên khóa 15DDS Đại học Nguyễn Tất Thành. Tạp chí Khoa học và Công nghệ (Đại học Nguyễn Tất Thành). 2020;số 12: 70–74.
Nguyễn Minh Thư, Dương Lê Hiền Thục, Nguyễn Thị Bảo Thanh, Nguyễn Huyền Trang, Trần Nhựt Linh, Trương Thành Nam. Nghiên cứu kiến thức, thực hành dự phòng phơi nhiễm nghề nghiệp với HIV/AIDS của sinh viên Trường Đại học Y dược Cần Thơ năm 2021. Tạp chí Y Dược học Cần Thơ.2022; 49:140–147.
Trung tâm kiểm soát dịch bệnh, Sở y tế Thành phố CầnThơ. Khảo sát, đánh giá thực trạng các dịch vụ phòng, chống HIV/AIDS tại Trường Đại học Cần Thơ [Internet]. Trung tâm Kiểm soát bệnh tật TP Cần Thơ. 2023. https:// cdccantho.vn/tin-tuc-su-kien-67/khao-sat-danh-gia-thuc-trang-cac-dich-vu-phong-chong-hiv-aids-tai-truong-dai-hoc-can-tho-1183.html.l
Nguyễn Ngọc Hà, Bùi Thị Hợi, Hoàng Hương Ly. Khảo sát thực trạng kiến thức và thái độ liên quan đến hành vi quan hệ tình dục của sinh viên Y - hệ chính quy tại Trường Đại học Y dược Thái Nguyên, năm 2016. Tạp chí Khoa hoc và Công nghệ Đại học Thái Nguyên.
;161(01):153–8.
Lâm Văn Minh, Nguyễn Thị Phương Thảo, Trương Thị Tường Vy, Nguyễn Thu Hà, Thành Sanh Nga, Lương Thị Thanh Lượng, Nguyễn Thị Minh Ngọc. Khảo sát kiến thức, thái độ của sinh viên khối ngành sức khỏe tại Trường Đại học Công nghệ Đồng Nai về chăm sóc sức khỏe sinh sản, năm 2022. Tạp chí Y học Việt Nam. 2023; 532(2): 363-369.
Family Planning - A global handbook for providers, 2022 edition [Internet]. [cited 2024 Dec 31]. Available from: https://www.who.int/publications/i/item/9780999203705
Folasayo AT, Oluwasegun AJ, Samsudin S, Saudi SNS, Osman M, Hamat RA. Assessing the Knowledge Level, Attitudes, Risky Behaviors and Preventive Practices on Sexually Transmitted Diseases among University Students as Future Healthcare Providers in the Central Zone of
Malaysia: A Cross-Sectional Study. Int J Environ Res Public Health. 2017 Feb 8;14(2):159.
Sleiman V, Obeid S, Sacre H, Salameh P, Hallit S, Hallit R. Knowledge, attitudes, and practices of Lebanese university students related to sexually transmitted diseases: a cross-sectional study. Croat Med J. 2023 Aug;64(4):213–21.
Zizza A, Guido M, Recchia V, Grima P, Banchelli F, Tinelli A. Knowledge, Information Needs and Risk Perception about HIV and Sexually Transmitted Diseases after an Education Intervention on Italian High School and University Students. Int J Environ Res Public Health. 2021
Feb 20;18(4):2069.
Wickham H. ggplot2: elegant graphics for data analysis. Second edition. Cham: Springer international publishing; 2016. 1 p. (Use R!).
Dorji T, Wangmo K, Tshering D, Tashi U, Wangdi K. Knowledge and attitude on sexually transmitted infections and contraceptive use among university students in Bhutan. PLOS ONE. 2022 Aug 3;17(8):e0272507.
Kaljee LM, Green M, Lerdboon P, Riel R, Pham V, Tho LH, et al. Parent-youth communication and concordance between parents and adolescents on reported engagement in social relationships and sexually intimate behaviors in Ha Noi and Khanh Hoa Province, Viet
Nam. J Adolesc Health. 2011 Mar;48(3):268–74.
Kaljee LM, Green M, Riel R, Lerdboon P, Tho LH, Thoa LTK, et al. Sexual Stigma, Sexual Behaviors, and Abstinence Among Vietnamese Adolescents: Implications for Risk and Protective Behaviors for HIV, STIs, and Unwanted Pregnancy. J Assoc Nurses AIDS Care.
;18(2):48–59.
Wong WCW, Lee A, Tsang KK. Correlates of Sexual Behaviors with Health Status and Health Perception in Chinese Adolescents: A Cross-Sectional Survey in Schools. AIDS Patient Care and STDs. 2004 Aug;18(8):470–80.
Drago F, Ciccarese G, Zangrillo F, Gasparini G, Cogorno L, Riva S, et al. A Survey of Current Knowledge on Sexually Transmitted Diseases and Sexual Behaviour in Italian Adolescents. Int J Environ Res Public Health. 2016 Apr;13(4):422.
Sexually transmitted infections (STIs): annual data [Internet]. GOV.UK. 2024 [cited 2025 Jan 2]. Available from: https://www.gov.uk/government/statistics/sexually-transmitted-infections-stis-annual-data-tables
Cunningham SD, Kerrigan DL, Jennings JM, Ellen JM. Relationships Between Perceived STD-Related Stigma, STD-Related Shame and STD Screening Among a Household Sample of Adolescents. Perspect Sex Reprod Health. 2009 Dec;41(4):225–30.
Marston C, King E. Factors that shape young people’s sexual behaviour: a systematic review. Lancet.
Nov 4;368(9547):1581–6.
Buhi ER, Daley EM, Oberne A, Smith SA, Schneider T, Fuhrmann HJ. Quality and Accuracy of Sexual Health Information Web Sites Visited by Young People. Journal of Adolescent Health. 2010 Aug 1;47(2):206–8.