Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Background: Cancer, infectious diseases, and oxidative stress remain major global health challenges, emphasizing the urgent need for natural compounds with potent biological activities. Goniothalamus tamirensis, a promising yet underexplored species of the genus Goniothalamus, has attracted interest for its potential pharmacological properties. Materials and Methods: The aerial parts of G. tamirensis extracts were evaluated for cytotoxic, antioxidant, and antimicrobial activities. Cytotoxicity was assessed by the SRB assay, antioxidant activity by the DPPH radical scavenging method, and antimicrobial activity by the broth dilution technique. Results: The ethyl acetate and methanol extracts exhibited strong cytotoxic effects against human breast, lung, and liver cancer cell lines with IC₅₀ values ranging from 7.72–16.87 µg/mL and 19.36–42.02 µg/mL, respectively. The methanol extract showed potent inhibition against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Lactobacillus fermentum), while the ethyl acetate extract was active against S. aureus and B. subtilis. Moreover, the n-hexane and ethyl acetate extracts displayed moderate antioxidant activity with IC₅₀ values of 30.15 and 19.08 µg/mL, respectively. Conclusion: Extracts of Goniothalamus tamirensis demonstrated significant cytotoxic, antimicrobial, and antioxidant potentials, suggesting this plant as a promising natural source for the development of bioactive agents.
| Published | 2026-06-28 | |
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| Issue | Vol. 16 No. 3 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.3.768 | |
| Keywords | Giác đế miên, gây độc tế bào ung thư, kháng vi sinh vật, chống oxy hóa |
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