Abstract
Background: Gastrointestinal bleeding is caused by a rupture of esophageal varices and is one of the common and serious complications in patients with cirrhosis. Early identification of esophagogastric varices and other mucosal features is really necessary for the preventive management, reducing the incidence of first bleeding and mortality. Objective: to describe esophagogastric mucosal changes on endoscopy in Child - Pugh A cirrhotic patients and investigate some factors associated to changes in upper gastrointestinal tract mucosa in these patients.
Methods: 70 cirrhotic patients with Child - Pugh A score were included in a cross-sectional descriptive study, at Hue University of Medicine and Pharmacy Hospital, Hue Central Hospital. Results: Esophageal varices 61.4%, gastric varices 8.6%, portal hypertensive gastropathy 44.3%. There are relationship between decreased prothrombin, spleen diameter, platelet count/spleen diameter ratio esophageal varices. ARFI correlates with esophageal varices at risk of bleeding.
Conclusion: Upper gastrointestinal endoscopy should be screened in cirrhotic patients with Child - Pugh A having ARFI higher than 20.5 kPa.
| Published | 2025-12-25 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | Vol. 15 No. 7 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.7.8 | |
| Keywords | nội soi, xơ gan Child - Pugh A endoscopy, cirrhosis with Child - Pugh class A |

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
LaBrecque D, Khan A, Sarin S, Le Mair A. Esophageal varices. World Gastroenterology Organisation global guidelines. WGO Milwaukee, WI, USA; 2014.
LaBrecque D, Khan A, Sarin S, Le Mair A. Esophageal varices. World Gastroenterology Organisation global guidelines. WGO Milwaukee, WI, USA; 2014.
Roccarina D, Best LM, Freeman SC, Roberts D, Cooper NJ, Sutton AJ, et al. Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta-analysis. Cochrane Database Syst Rev. 2021;4(4):Cd013121.
De Franchis R, Faculty BV. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. Journal of hepatology. 2015;63(3):743-52.
Augustin S, Pons M, Santos B, Ventura M, Genescà J, editors. Identifying compensated advanced chronic liver disease: when (not) to start screening for varices and clinically significant portal hypertension. Portal Hypertension VI: Proceedings of the Sixth Baveno Consensus Workshop: stratifying risk and individualizing care; 2016: Springer.
Maurice JB, Brodkin E, Arnold F, Navaratnam A, Paine H, Khawar S, et al. Validation of the Baveno VI criteria to identify low risk cirrhotic patients not requiring endoscopic surveillance for varices. Journal of hepatology. 2016;65(5):899-905.
Abraldes JG, Bureau C, Stefanescu H, Augustin S, Ney M, Blasco H, et al. Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The “Anticipate” study. Hepatology. 2016;64(6):2173-84.
Paternostro R, Kapzan L, Mandorfer M, Schwarzer R, Benedikt S, Viveiros A, et al. Anemia and iron deficiency in compensated and decompensated cirrhosis: Prevalence and impact on clinical outcomes. Journal of gastroenterology and hepatology. 2020;35(9):1619-27.
Hà Vũ, Huỳnh Anh Đức, et al.
Khảo sát mối tương quan giữa phân loại Child– Turcotte–Pugh và mức độ giãn tĩnh mạch thực quản ở bệnh nhân xơ gan. Y học TP Hồ Chí Minh. 2017;21(1):141–6.
Scaglione S, Kliethermes S, Cao G, Shoham D, Durazo R, Luke A, et al. The epidemiology of cirrhosis in the United States: a population-based study. Journal of clinical gastroenterology. 2015;49(8):690-6.
Qi X, Han G, Wu K, Fan D. A confusing relationship between Child–Turcotte–Pugh Class A and compensated cirrhosis. Official journal of the American College of Gastroenterology| ACG. 2010;105(2):470-2.
Park Y, Kim SU, Park SY, Kim BK, Park JY, Kim DY, et al. A novel model to predict esophageal varices in patients with compensated cirrhosis using acoustic radiation force impulse elastography. PloS one. 2015;10(3):e0121009.
Trần Văn Huy, Hồ Anh Hiến. Nghiên cứu hình ảnh nội soi niêm mạc thực quản dạ dày ở các bệnh nhân xơ gan. . Tạp chí Y Dược học Huế. 2011(21 (5), 45).
De Lisi S, Peralta S, Arini A, Simone F, Craxì A. Oesophagogastroduodenoscopy in patients with cirrhosis: extending the range of detection beyond portal hypertension. Digestive and Liver Disease. 2011;43(1):48- 53.
Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long‐term follow‐up study in 568 portal hypertension patients. Hepatology. 1992;16(6):1343-9.
Svoboda P, Konecny M, Martinek A, Hrabovsky V, Prochazka V, Ehrmann J. Acute upper gastrointestinal bleeding in liver cirrhosis patients. Biomedical Papers. 2012;156(3):266-70.
Bang CS, Kim HS, Suk KT, Kim SE, Park JW, Park SH, et al. Portal hypertensive gastropathy as a prognostic index in patients with liver cirrhosis. BMC gastroenterology. 2016;16(1):93.
Voulgaris T, Karagiannakis D, Siakavellas S, Kalogera D, Angelopoulos T, Chloupi E, et al. High prevalence of asymptomatic peptic ulcers diagnosed during screening endoscopy in patients with cirrhosis. Annals of gastroenterology. 2019;32(5):451.
Venkatesh PG, Parasa S, Njei B, Sanaka MR, Navaneethan U. Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. Gastrointestinal endoscopy. 2014;79(4):605-14. e3.
Đặng Thị Kim Oanh. Nghiên cứu hình ảnh nội soi và mô bệnh học của niêm mạc dạ dày thực quản ở bệnh nhân xơ gan.: Đại học Y Hà Nội; 2002.
Trần Phạm Chí. Nghiên cứu hiệu quả thắt giãn tĩnh mạch thực quản kết hợp Propranolon trong dự phòng xuất huyết tái phát và tác động lên bệnh dạ dày tăng áp cửa do xơ gan. Đại học Huế: Đại học Huế; 2014.
Trần Ngọc Lưu Phương, Nguyễn Thị Cẩm Tú, et al. Khảo sát đặc điểm nội soi dạ dày–thực quản trên bệnh nhân xơ gan. Tạp chí Y học TP Hồ Chí Minh. 2010;14(2):95– 101.





