Abstract
Background: Lumbar spine surgery is associated with a high level of postoperative pain, ranking only after thoracic and upper abdominal surgeries. Inadequate postoperative pain control in spine surgery not only affects treatment outcomes but also increases the risk of postoperative complications. Gabapentin, a medication with neuropathic pain-relieving properties, has been shown in several studies to effectively reduce postoperative pain following spine surgery. However, the number of studies evaluating the analgesic efficacy of gabapentin after lumbar spine surgery remains limited. Therefore, we conducted this study to assess the effectiveness of gabapentin in patients undergoing lumbar spine surgery, focusing on its analgesic efficacy, recovery quality using the QoR-15 score, and potential adverse effects.
Materials and method: A Randomized Controlled Trial was conducted on patients undergoing elective lumbar spine surgery between June 2023 and September 2024. The patients were divided into two groups (30 patients in each group). The gabapentin group Lumbar spine surgery is associated with a high level of postoperative pain, ranking only after thoracic and upper abdominal surgeries received an oral dose of 600 mg gabapentin 3 hours before surgery, while the control group did not receive gabapentin. Postoperatively, both groups were managed with a multimodal analgesia regimen, including intravenous paracetamol and nefopam infusions, intravenous ketorolac, and patient-controlled intravenous morphine analgesia.
Results: The gabapentin group demonstrated lower VAS scores and 24-hour morphine consumption, along with better recovery quality as measured by the QoR-15 scale compared to the control group. There was no significant difference in adverse effects between the two groups.
Conclusion: Preoperative use of gabapentin is effective in pain relief and enhances recovery quality following lumbar spine surgery.
| Published | 2025-12-25 | |
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| Issue | Vol. 15 No. 7 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.7.27 | |
| Keywords | Gabapentin, phẫu thuật cột sống thắt lưng, giảm đau đa mô thức Gabapentin, lumbar spine surgery, multimodal analgesia |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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