Abstract
Background: Among various nanotechnology-based formulation techniques, the “top-down” approach, particularly wet milling, demonstrates significant potential for practical applications due to its simple process and scalability. However, the properties of the nanosystems are strongly influenced by formulation variables and process parameters. Therefore, investigating the effects of these factors is essential to improve the physicochemical properties of tinidazole, a poorly water-soluble drug, in nanoparticle form.
Objectives: This study aimed to evaluate the effect of formulation components and process parameters on the characteristics of tinidazole nanoparticles prepared by ball milling.
Materials and methods: Tinidazole, hydroxypropyl methylcellulose E6 (HPMC E6), sodium lauryl sulfate, and other chemicals were utilized. The tinidazole nanosuspension was prepared via ball milling. The effects of formulation factors (type and concentration of polymers and surfactants) and process parameters (milling time and bead mass) were evaluated based on particle size, polydispersity index (PDI), drug content after centrifugation, and other physicochemical characteristics of the nanosystem.
Results: Both formulation factors and ball-milling parameters significantly affected the properties of the tinidazole nanosuspensions. The optimized nanosuspension containing 3.3% tinidazole, stabilized by a combination of 4% HPMC E6 and 0.2% sodium lauryl sulfate dispersed in water, exhibited a particle size below 400 nm with a PDI less than 0.3. The nanosuspension demonstrated a marked improvement in dissolution rate compared to the raw suspension.
Conclusion: This study elucidated the effect of formulation variables and ball-milling process parameters on the physicochemical properties of tinidazole nanoparticles and identified suitable formulation and processing conditions to obtain a stable nanosystem. The results provide a foundation for further research on incorporating this nanosystem into final dosage forms.
| Published | 2026-06-28 | |
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| Issue | Vol. 16 No. 3 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.3.862 | |
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Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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