Abstract
Background: Approximately 25% of congenital heart disease (CHD) cases present symptoms during the neonatal period. These cases are classified as critical CHD, requiring immediate medical intervention or treatment. Preoperative stabilization plays a pivotal role in determining the prognosis, particularly for neonates.
Subjects and Methods: This cross-sectional descriptive study with longitudinal follow-up included 39 neonates diagnosed with critical CHD via Doppler echocardiography at Hue Central Hospital from July 2022 to April 2023.
Results: Ductal-dependent CHD was the most prevalent, accounting for 56.4% of cases, with 41% classified as ductal-dependent pulmonary circulation CHD. The most common clinical manifestations among neonates were cyanosis (51.3%) and heart murmur (46.2%). Prostaglandin therapy to maintain ductal patency was administered in 35.9% of cases. The mortality rate during preoperative stabilization was 25.6%. Risk factors associated with preoperative mortality in neonates with critical CHD included: Birth weight < 2500 grams (OR = 4.71, 95% CI: 1.03–21.65, p < 0.05); Invasive mechanical ventilation (OR = 23.62, 95% CI: 2.56–217.7, p < 0.05; Heart failure treatment (OR = 8.88, 95% CI: 1.56–50.5, p < 0.05); Inotropic support (OR = 8.67, 95% CI: 1.55–48.5, p < 0.05). Conclusions: Preoperative mortality risk in neonates with critical CHD is significantly increased by low birth weight (< 2500 grams), the need for invasive mechanical ventilation, heart failure treatment, and inotropic support.
| Published | 2025-12-30 | |
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| Issue | Vol. 15 No. 6 (2025) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2025.6.884 | |
| Keywords | Newborn, critical congenital heart disease, mortality |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Hue Journal of Medicine and Pharmacy
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