Clinical and Laboratory Characteristics and Associated Factors to Mortality in Neonates with Birth Asphyxia: A Prospective Observational Study

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CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học

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Aims: To describe the clinical and laboratory characteristics and to investigate associated factors with mortality of birth asphyxia. Methods: This was a prospective observational study conducted on a total of 120 asphyxiated neonates admitted to the Neonatal Intensive Care Unit (NICU). Results: Severe asphyxia was observed in 33.3%, and moderate asphyxia in 66.7% of the cases. The mortality rate was 19.2%. The common clinical features: apnea/gasping (45.8%), hypothermia (37.5%), lethargy (33.0%). The serious clinical signs: abnormal heart rate (15.8%), gastrointestinal bleeding (13.3%), oliguria and anuria (17.5%). The laboratory findings showed hypoglycemia (30.8%), elevated SGOT (45.0%), serum creatinine > 133 μmol/l (31.7%), hyponatremia (35.0%), hypocalcemia (65.8%), elevated lactate > 5mmol/l (53.6%). The factors that increased the risk of mortality in neonatal asphyxia were Apgar score at 5 min ≤ 5, seizure/coma, need for mechanical ventilation, serum creatinine > 133 μmol/l, liver injury, and lactate ≥ 5 mmol/l. Conclusion: The mortality rate is still high, and elevated serum creatinine, elevated liver enzymes, elevated lactate, and low 5-minute Apgar scores increase the risk of death in asphyxiated neonates.
https://doi.org/10.34071/jmp.2023.6.6
Đã xuất bản 01-12-2023
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Số tạp chí Tập 13 Số 6 (2023)
Phân mục Nghiên cứu
DOI 10.34071/jmp.2023.6.6
Từ khóa birth asphyxia, mortality, risk factors, neonates. birth asphyxia, mortality, risk factors, neonates.

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Bản quyền (c) 2023 Tạp chí Y Dược Huế

Nguyen, T. T. B., Vu, T. D. H., & Tran, B. T. (2023). Clinical and Laboratory Characteristics and Associated Factors to Mortality in Neonates with Birth Asphyxia: A Prospective Observational Study. Tạp Chí Y Dược Huế, 13(6), 64–71. https://doi.org/10.34071/jmp.2023.6.6