Tóm tắt
Background: Sepsis remains a leading cause of hospital mortality worldwide, placing significant pressure on healthcare systems. Therefore, investigating severe prognostic factors in patients with sepsis is crucial for improving prevention and treatment outcomes.
Objective: To describe clinical and laboratory characteristics and evaluate severe prognostic factors for severity and mortality in patients with sepsis.
Methods: A cross-sectional descriptive study was conducted on 107 patients admitted to the Intensive Care Unit (ICU) at Hue Central Hospital from September 2024 to November 2024. Data were collected from medical records and patient/relative interviews. Statistical analysis included Receiver Operating Characteristic (ROC) curves to determine the Area Under the Curve (AUC) for prognostic factors.
Results: The mean age was 64.44 ± 15.75 years. The incidence of septic shock was 60.7% (65/107), and the mortality rate was 48.6% (52/107). Regarding prognostic factors for severity: Procalcitonin (PCT) at a cutoff of 7.012 ng/mL had a sensitivity of 89.2% and specificity of 78.2%; Lactate at a cutoff of 2.395 mmol/L had a sensitivity of 93.8% and specificity of 78.6%. Regarding mortality prediction: The SOFA and APACHE II scores showed significant predictive value, with SOFA (AUC 0.907) demonstrating high specificity (98.2%) for mortality risk.
Conclusion: PCT and blood lactate levels are valuable for predicting severe outcomes in sepsis patients. Furthermore, the SOFA and APACHE II scoring systems are useful in predicting progression to septic shock and mortality in the study population.
| Đã xuất bản | 30-12-2025 | |
| Toàn văn |
|
|
| Ngôn ngữ |
|
|
| Số tạp chí | Tập 15 Số 6 (2025) | |
| Phân mục | Nghiên cứu | |
| DOI | 10.34071/jmp.2025.6.565 | |
| Từ khóa | Dengue hemorrhagic fever, nutrient (ying), defense (wei), vital energy (qi), blood (xue), traditional medicine. : Sốt Dengue xuất huyết, dinh, y học cổ truyền, vệ, khí, huyết |
công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .
Bản quyền (c) 2025 Tạp chí Y Dược Huế
Brady, Oliver J. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PloS Negl Trop Dis. 2012; 6(8):1760-1762.
World Health Organization. Dengue and severe dengue. Geneva; 2023.
World Health Organization. Dengue increase likely during rainy season, Ministry of Health, WHO warn. Geneva; 2023.
Ministry of Health. Guidelines for diagnosis and treatment of Dengue fever. Ministry of Health Guidelines; 2023.
Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy. Infectious diseases in traditional medicine. 2020. p. 40-47.
Le VP, Phan TT, Nguyen TPT, Tran XC. Study on some severe prognostic factors in adult Dengue fever patients. Hue Journal of Medicine and Pharmacy. 2016;6(02):94-99.
Doum D, Overgaard H J, Mayxay M, Suttiprapa S, et al, “Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos”, International journal of environmental research and public health 2020; 17(23): 9134.
Nguyen VL. Study on platelet count variations and their correlation with disease progression and prognosis in adult Dengue fever patients [Doctoral thesis]. Hue University of Medicine and Pharmacy; 2019.
Fujimoto D E, Koifman S, “Clinical and laboratory characteristics of patients with Dengue hemorrhagic fever manifestations and their tranfusion profile”, Revista brasileira de hematologia e hemoterapia 2014 Mar; 36(2):115-120.
叶志中,刘南,余锋,赵静.210例登革热患者中医证候分析.广州中医药大学学报. 2014;8(12):15-17.
Faculty of Traditional Medicine, Hue University of Medicine and Pharmacy. Study on Warm Diseases in Traditional Medicine. 2024. p. 1-14.
韩凡,莫锦,覃小兰.从257例病例中探讨登革热的中医临床辨治.2014年中华中医药学会急诊分会年会.2013;7(6):192-198.
刘昶权,张国明.2019年广东省480例登革热住院患者的流行病学和临床特征分析.中华传染病杂志.2019;39(4):209-213.
于翠香,叶晓燕,王俊峰.125例登革热患者临床特点及护理.中文科技期刊数据库.2008;15(11):850-851.