Study on outcomes of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for the diagnosis of pancreatic tumors

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CÁC SỐ TỪ 2011-2023
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Abstract

Background: Pancreatic cancer is a highly malignant disease. Endoscopic ultrasound guided fine-needle  biopsy is a novel technique for obtaining tissue samples to aid in the diagnosis of pancreatic cancer. However,  its effectiveness and safety have not been extensively studied in Vietnam.  

Objectives: 1. To determine the results of endoscopic guided fine needle biopsy (EUS-FNB) in patients with  suspected pancreatic cancer; 2. To examine some correlations between the technical parameters and the  results of EUS-FNB in patients with suspected pancreatic cancer. 

Subjects and methods: Descriptive cross-sectional study on patients with suspected pancreatic cancer based  on EUS-FNB specimens.  

Results: A total of 81 patients were diagnosed with pancreatic cancer. EUS-FNB provided a diagnostic result  on the first attempt in 92.6% of cases, on the second attempt in 6.2%, and on the third attempt in 1.2%. The  overall complication rate was 4.9%, including minor bleeding along the needle puncture tract and transient abdominal pain. All complications were self-limiting and required no intervention. The mean number of needle  passes was 1.69 ± 0.664. There was no significant difference in the mean number of needle passes between  19G, 20G and 22G needles (P = 0.285). There was a significant difference in suction pressure between 19G  and 22G needles when obtaining standard tissue samples based on Macroscopic On-Site Evaluation (MOSE). 

Conclusion: EUS-FNB achieved high diagnostic yield for pancreatic cancer most commonly after the first  needle pass, with a low rate of mild, self - limited complications. There is no significant difference in the mean  number of needle passes among different needle types, and suction may not be necessary when performing  EUS-FNB with a 19G needle. 

https://doi.org/10.34071/jmp.2026.1.1033
Published 2026-03-30
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Issue Vol. 16 No. 1 (2026)
Section Original Articles
DOI 10.34071/jmp.2026.1.1033
Keywords EUS-FNB, ung thư tụy, nội soi siêu âm EUS-FNB, pancreatic cancer, Endoscopic Ultrasound

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Trịnh , P. M. L., Hồ , Đăng Q. D., Trần , Đình T., & Trần , V. H. (2026). Study on outcomes of Endoscopic Ultrasound-Guided Fine-Needle Biopsy for the diagnosis of pancreatic tumors. Hue Journal of Medicine and Pharmacy, 16(1), 157–163. https://doi.org/10.34071/jmp.2026.1.1033

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-63.

Kim NH, Kim HJ. How to optimize the diagnostic yield of endoscopic ultrasound-guided fine-needle sampling in solid pancreatic lesions from a technical perspective. Int J Gastrointest Interv 2023;12(2):57-63.

Rawla P, Sunkara T, Gaduputic V. Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J Oncol. 2019; 10(1):10-27.

Ashida R, Tanaka S, Yamanaka H, Okagaki S, Nakao K, Fukuda J, et al. The Role of Transabdominal Ultrasound in the Diagnosis of Early Stage Pancreatic Cancer: Review and Single-Center Experience. Diagnostics 2019;9(1):2.

Yoshida T, Yamashita Y, Kitano M. Endoscopic Ultrasound for Early Diagnosis of Pancreatic Cancer. Diagnostics (Basel) 2019;9(3):81.

Su Y-Y, Liu Y-S, Chao Y-J, Chiang N-J, Yen C-J, Tsai H-M. Percutaneous Computed Tomography-Guided Coaxial Core Biopsy for the Diagnosis of Pancreatic Tumors. Journal of Clinical Medicine. 2019;8(10):14.

Levine I, Trindade AJ. Endoscopic ultrasound fine needle aspiration vs fine needle biopsy for pancreatic masses, subepithelial lesions, and lymph nodes. World J Gastroenterol. 2021;27(26):4194-207.

Masuda S, Koizumi K, Shionoya K, Jinushi R, Makazu M, Nishino T, et al. Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor. World J Gastroenterol. 2023;29(12):1863-74.

Cheng B, Zhang Y, Chen Q, Sun B, Deng Z, Shan H, et al. Analysis of Fine-Needle Biopsy vs Fine-Needle Aspiration in Diagnosis of Pancreatic and Abdominal Masses: A Prospective, Multicenter, Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2018;16(8):1314-21.

Renelus BD, Jamorabo DS, Boston I, Briggs WM, Poneros JM. Endoscopic Ultrasound-Guided Fine Needle Biopsy Needles Provide Higher Diagnostic Yield Compared to Endoscopic Ultrasound-Guided Fine Needle Aspiration Needles When Sampling Solid Pancreatic Lesions: A Meta Analysis. Clin Endosc. 2021;54(2):261-8.

Bellocchi MCC, Bernuzzi M, Brillo A, Bernardoni L, Amodio A, Pretis ND, et al. EUS-FNA versus EUS FNB in Pancreatic Solid Lesions ≤ 15 mm. Diagnostics. 2024;14(4):427.

Iwashita T, Yasuda I, Mukai T, Doi S, Nakashima M, Uemura S, et al. Macroscopic on-site quality evaluation of biopsy specimens to improve the diagnostic accuracy during EUS-guided FNA using a 19-gauge needle for solid lesions: a single-center prospective pilot study (MOSE study). Gastrointest Endosc. 2015;81(1):177-85.

Bang JY, Jhala N, Seth A, Krall K, Navaneethan U, Hawes R, et al. Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial. Gut. 2023;72:1255–7.

Camus B, Pellat A, Rouquette A, Marchese U, Dohan A, Belle A, et al. Diagnostic Yield of Repeat Endoscopic Ultrasound-Guided Fine Needle Biopsy for Solid Pancreatic Lesions. Cancers. 2023;15:3745.

Yang MJ, Park SW, Lee KJ, Koh DH, Lee J, Lee YN, et al. EUS-guided tissue acquisition using a novel torque technique is comparable with that of the fanning technique for solid pancreatic lesions: A multicenter randomized trial. J Hepatobiliary Pancreat Sci. 2023;30(5):693-703.

Chalhoub JM, Hawa F, Grantham T, Mendoza-Lada A, Wani S, Machicado JD. Effect of the number of passes on diagnostic performance of EUS fine-needle biopsy of solid

pancreatic masses: a systematic review and meta-analysis. Gastrointestinal Endoscopy. 2024;Published online: June 06, 2024.

Paik WH. Endoscopic ultrasound-guided tissue acquisition: Needle types, technical issues, and sample handling. Int J Gastrointest Interv. 2022;11:96-101.

Affronti J. Pancreas lesion size and EUS-guided tissue sampling. Gastrointestinal Endoscopy. 2024;99(1):81-2. 19. Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388(10039):73-85.

Bang JY, Krall K, Jhala N, Singh C, Tejani M, Arnoletti JP, et al. Comparing Needles and Methods of Endoscopic Ultrasound-Guided Fine-Needle Biopsy to Optimize Specimen Quality and Diagnostic Accuracy for Patients With Pancreatic Masses in a Randomized Trial. Clin Gastroenterol Hepatol. 2021;19(4):825-35.