Indexing
CÁC SỐ TỪ 2011-2023
Tạp chí Y Dược Học
Abstract
Introduction: Epilepsy is a common neurological disorder that affects about 4.4 in every 1000 Vietnamese. The prevalence of medically refractory epilepsy is estimated at 36.3% of the patients with epilepsy who are treated and managed at all medical facilities. Lesionectomy surgery is an effective treatment method for drug-resistant epileptic patients, and the success rate could be up to 86.5%. However, in Vietnam, the number of patients treated with this method is still low, and few studies have been published.
Objective: To evaluate the outcomes of epilepsy surgery in a limited-resource hospital in Vietnam.
Method and Population Study: The population study is drug-resistant epileptic patients who underwent epilepsy surgery at our institution from February 2022 to March 2025. A medically refractory epilepsy diagnosis is established when a patient still has a seizure while treated with two antiseizure medications at maximum doses. Patients underwent presurgical evaluation including physical examination, brain MRI, and video EEG telemetry. Epileptic patients with detectable lesions in eloquent areas were excluded from the study. Outcomes were evaluated based on the Engel classification.
Results: From February 2022 to March 2025, 27 drug-resistant epileptic patients underwent lesionectomy surgery, and three patients underwent callosotomy. Postoperatively, among 27 patients undergoing (81.5%) had Engel I, 3 cases (11.1%) had Engel II, and 2 cases (7.4%) had Engel III. Three patients undergoing corpus callosotomy had favorable outcomes with a 70-80% reduction in the frequency of seizures.
Conclusion: Epilepsy surgery for patients with medically refractory epilepsy is safe and effective in a limited resource hospital.
| Published | 2026-03-30 | |
| Fulltext |
|
|
| Language |
|
|
| Issue | Vol. 16 No. 1 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.1.1035 | |
| Keywords | Động kinh kháng trị, xơ hóa hải mã, phẫu thuật động kinh, kháng trị, loạn sản vỏ não khu trú refractory epilepsy, hippocampal sclerosis, epilepsy surgery, focal cortical dysplasia |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
Tuan NA, Cuong LQ, Allebeck P, Chuc NTK, Persson HE, Tomson T. The prevalence of epilepsy in a rural district of Vietnam: a population-based study from the EPIBAVI project. Epilepsia. 2008;49(9):1634-1637.
Sultana B, Panzini MA, Veilleux Carpentier A, et al. Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis. Neurology. 2021;96(17):805-817.
Rugg-Gunn F, Miserocchi A, McEvoy A. Epilepsy surgery. Pract Neurol. 2020;20(1):4-14.
Mehvari Habibabadi J, Moein H, Jourahmad Z, et al. Outcome of epilepsy surgery in lesional epilepsy: Experiences from a developing country. Epilepsy Behav. 2021;122:108221.
Le V, Thuy Le M, Nguyen DH, et al. Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model. Epilepsia Open. 2022;7(4):710-717.
Thuy Le MA, Fong SL, Lim KS, et al. Underutilization of epilepsy surgery in ASEAN countries. Seizure. 2019;69:51-56.
Engel JJ, Van Ness P, Rasmussen T, Ojemann L. Outcome with Respect to Epileptic Seizures. In Engel J Jr, Ed. Surgical Treat- Ment of the Epilepsies. Engel J Jr, ed. Surgical treatment of the epilepsies. Raven Press; 1993.
Wu X, Ou S, Zhang H, et al. Long-term follow-up seizure outcomes after corpus callosotomy: A systematic review with meta-analysis. Brain Behav. 2023;13(4):e2964.
Liu Y, Wu H, Li H, et al. Severity Grading, Risk Factors, and Prediction Model of Complications After Epilepsy Surgery: A Large-Scale and Retrospective Study. Front Neurol. 2021;12:722478.
Sultana B, Panzini MA, Veilleux Carpentier A, et al. Incidence and Prevalence of Drug-Resistant Epilepsy: A Systematic Review and Meta-analysis. Neurology. 2021;96(17):805-817.