Abstract
Objective: To indirectly quantify iron content in deep gray matter nuclei based on phase image values using susceptibility-weighted imaging (SWI) at Hue University Hospital.
Methods: A cross-sectional descriptive study was conducted on 62 patients who underwent brain MRI, including Susceptibility-Weighted Imaging (SWI) sequences, between March 2023 and April 2024. The MRI reports showed no abnormalities in the routine pulse sequences. The phase shift of central gray matter nuclei was measured from the phase image of the SWI. Descriptive statistics and paired t-tests were used to compare variables by sex and side (left/right). Correlation analysis was performed to evaluate the relationship between these variables and age. Statistical significance was set at p < 0.05.
Results: The highest iron concentration was observed in the thalamus, followed in descending order by the putamen, red nucleus, substantia nigra globus pallidus, caudate nucleus. Patient age showed a positive correlation with iron deposition in the caudate nucleus, putamen, globus pallidus, thalamus, and substantia nigra (p < 0.05). The putamen exhibited the strongest correlation with age (r > 0.5; p < 0.05). Variations in iron concentration between the two hemispheres were identified in the putamen, globus pallidus, and red nucleus. Significant differences between males and females were found in the red nucleus and globus pallidus (p < 0.05).
Conclusion: Increased iron deposition associated with advancing age was identified in the caudate nucleus, putamen, globus pallidus, thalamus, and substantia nigra. Iron accumulation patterns differed between hemispheres: higher concentrations were noted in the right hemisphere for the putamen, whereas the left hemisphere showed greater deposition in the globus pallidus and red nucleus.
| Published | 2026-09-28 | |
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| Issue | Vol. 16 No. 5 (2026) | |
| Section | Original Articles | |
| DOI | 10.34071/jmp.2026.5.1055 | |
| Keywords | lắng động sắt, nhân xám trung ương, chuỗi xung nhạy cảm từ SWI |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2026 Hue Journal of Medicine and Pharmacy
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